Influence of Serum Vitamin D Levels on Survival Rate and Marginal Bone Loss in Dental Implants: A Systematic Review.

This systematic literature review set out to investigate the relationship between serum vitamin D levels and dental implants in terms of survival rates, marginal bone loss, and associated complications. The review was conducted according to PRISMA guidelines, performing an electronic search in four databases (Pubmed, Web of Science, Cochrane, and Scopus), complemented by a manual search up to April 2022. Four articles were selected for analysis. The Newcastle-Ottawa Quality Assessment Scale tool was used to assess the quality of evidence of cohort studies, and the Cochrane bias assessment tool was used to assess the quality of evidence of randomized clinical trials. The study included 1089 patients restored with 1984 dental implants, with follow-up periods ranging from 20-240 months. Cases presenting lower serum vitamin D levels obtained slightly worse results in terms of marginal bone loss. Longer follow-up periods are needed in order to determine whether serum vitamin D levels affect implant survival rates and osseointegration over time.

Implante inmediato postextracción en zona de alto compromiso estético utilizando la técnica del "Socket Shield", provisional inmediato y prótesis definitiva con un pilar transepitelial customizado de circonio / Immediate post-extraction implant in a high aesthetic area using "Socket Shield" technique, immediate provisional, and definitive prosthesis with a customized zirconia transepithelial abutment

El objetivo de este trabajo es demostrar la estabilidad de los tejidos que rodean a un implante inmediato tras la realización de una extracción parcial de un diente. La técnica de Socket Shield fue descrita por primera vez por Hürzeler y cols., con la finalidad de preservar el volumen y la posición de los tejidos, así como el nivel original de la cortical vestibular tras la exodoncia, manteniendo un fragmento de la raíz dental a la par que se inserta un implante dental en el mismo alveolo y respetando una distancia entre ambos de uno o dos milímetros y que deberá ser ocupado por el coágulo sanguíneo. A continuación, se expone un caso clínico de una mujer de 42 años de edad que acudió de urgencia por una fractura dental en zona estética. El plan de tratamiento implica la extracción del incisivo central superior derecho y su posterior rehabilitación fija. Se colocó un implante Biohorizons(R) a 40N, 72 ISQ, postextracción y empleando la técnica de Socket-shield con una restauración inmediata temporal no funcional. Transcurridas 16 semanas, se conectó un pilar transepitelial personalizado de circonio y se cementó la corona Emax2. Transcurridos 12 meses de carga funcional, no ha habido complicaciones quirúrgicas ni protésicas. El volumen y la forma original de la cortical vestibular no se han visto clínicamente alteradas, el fragmento radicular se encuentra estable y los tejidos blandos circundantes están en armonía con el pilar transepitelial de circonio, cuya altura de 4 mm aleja la interfase pilar-corona de la interfase pilar-implante en pro de la estabilidad tisular en ese plano. Se ha conseguido estabilizar los tejidos periimplantarios con la técnica Socket Shield y salvaguardar el compromiso estético que implica la pérdida de un incisivo central superior

The objective of this work is to demonstrate the stability of the tissues surrounding an inmediate implant after performing a partial extraction. The Socket Shield technique was described by Hürzeler et all in 2010 with the main goal of preserve the volume and the initial position of the soft-tissues and the buccal plate after the tooth extraction, keeping a piece of the buccal dental root into the alveolar socket at same time of the dental implantation, maintaining a security distance of 1 or 2 millimetres, that should be occupied by the blood cloth. In this Clinical case, a female of 42 years old, with a broken teeth's crown requires dental implant treatment. The planning needs teeth extraction at the upper maxilla and posterior rehabilitation with fixed implant prosthesis. It was inserted a Biohorizons(R) dental implant, using the Socket Shield technique after the partial extraction of the teeth. An immediate provisional prosthesis was connected. 16 weeks later; it was substituted by a customized zirconia abutment to make prosthesis over it. After 12 months of functional load, nonsurgical or prosthesis complications were described. The volume and the original shape of the buccal bone plate do not showed clinical changes, the root piece is stable and the zirconia customized abutment maintains an implant rehabilitation connection far away of the biological width. The Socket Shield technique stabilizes the periimplant tissues and preserves the biological width of the immediate dental implant using a customized zirconia abutment

Estabilización clínica de los tejidos periimplantarios mediante la combinación de la técnica "Socket Shield" y el pilar múltiple PGMU2 / Clinical stabilization of the periimplant tissues with the combination of the socket shield technique and the PGMU2 abutment

La técnica de Socket Shield fue descrita por primera vez por Zuhr y cols., en el año 2010 con la finalidad de preservar el volumen y la posición de los tejidos, así como el nivel original de la cortical vestibular tras la exodoncia, manteniendo un fragmento de la raíz dental a la par que se inserta un implante dental en el mismo alveolo y respetando una distancia entre ambos de uno o dos milímetros y que deberá ser ocupado por el coágulo sanguíneo. Caso clínico de un varón de 79 años de edad, con edentulismo parcial que es diagnosticado para tratamiento implantológico. El plan de tratamiento implica la extracción de dientes remanentes en maxilar superior y su posterior rehabilitación fija. Se colocaron dos implantes Biohorizons(R), uno de ellos postextracción, empleando la técnica de Socket-shield. Transcurridas 12 semanas, se conectó un pilar de cicatrización, 5 semanas después, se sustituyó el tapón por un pilar múltiple tipo Multi-unit(R) para confeccionar la prótesis fija. Transcurridos 12 meses de carga funcional, no habido complicaciones quirúrgicas ni protésicas. El volumen y la forma original de la cortical vestibular no se ha visto clínicamente alterada, el fragmento radicular se encuentra estable y el pilar PGMU2 ha permitido la rehabilitación del implante alejando la conexión de la prótesis del espacio biológico. Se ha conseguido estabilizar los tejidos periimplantarios con la técnica Socket Shield y salvaguardar el espacio biológico del implante inmediato con el pilar múltiple

The Socket Shield technique was described by Zuhr et all in 2010 with the main goal of preserve the volume and the initial position of the soft-tissues and the buccal plate after the tooth extraction, keeping a piece of the buccal dental root into the alveolar socket at same time of the dental implantation, keeping a security distance of 1 or 2 millimetres, that it should be occupied by the blood cloth. In this Clinical case, a male of 79 years old with partial edentulism requires dental implant treatment. The planning needs tooth extractions at the upper maxilla and posterior rehabilitation with fixed implant prosthesis. It was inserted two Biohorizons(R)dental implants, one of theme was after tooth extraction and using the Socket Shield technique. After 12 weeks, it was connected a healing abutment, 5 weeks later, It was substituted by a Multi-unit(R) abutment to make a prosthesis over it. After 12 months of functional load, non-surgical or prosthesis complications were described. The volume and the original shape of the buccal bone plate do not showed clinical changes, the root piece is stable and the PGMU2 abutment maintains an implant rehabilitation connection far away of the biological width. The Socket Shield technique stabilizes the periimplant tissues and preserves the biological width of the immediate dental implant using a Muti-unit(R) abutment

Functional insights into the cellular response triggered by a bile-acid platinum compound conjugated to biocompatible ferric nanoparticles using quantitative proteomic approaches.

At present, bioferrofluids are employed as powerful multifunctional tools for biomedical applications such as drug delivery, among others. The present study explores the cellular response evoked when bile-acid platinum derivatives are conjugated with bioferrofluids by testing the biological activity in osteosarcoma (MG-63) and T-cell leukemia (Jurkat) cells. The aim of this work is to evaluate the biocompatibility of a bile-acid platinum derivative conjugated with multi-functional polymer coated bioferrofluids by observing the effects on the protein expression profiles and in intracellular pathways of nanoparticle-stimulated cells. To this end, a mass spectrometry-based approach termed SILAC has been applied to determine in a high-throughput manner the key proteins involved in the cellular response process (including specific quantitatively identified proteins related to the vesicular transport, cellular structure, cell cycle, biosynthetic process, apoptosis and regulation of the cell cycle). Finally, biocompatibility was evaluated and validated by conventional strategies also (such as flow cytometry, MTT, etc.).

Enhanced cytotoxic activity of bile acid cisplatin derivatives by conjugation with gold nanoparticles.

This article explores the potential cytotoxic activity of bile-acid cisplatin derivatives like bisursodeoxycholate(ethylenediamine)platinum(II), PtU2, when conjugated with gold nanoparticles, being a promising alternative to cisplatin in the treatment of cancer due to their lower toxicity. For our purpose we analyzed the intracellular delivery ability of these compounds after conjugation with 20-nm gold nanoparticles (PtU2-AuNPs) in the MG63 (osteosarcoma) cell line. Same platinum uptake after incubation with PtU2 and PtU2-AuNPs-derivatives is associated with a higher cytotoxic activity in case of the platinum-gold nanoparticle conjugate, the overall IC50 of PtU2 being reduced more than 10 fold for these new conjugates. When conjugated with gold nanoparticles, this bile-acid derivative is more efficient than the platinum compound alone in terms of their cytotoxic activity.

Platinum complexes for multi-parametric assays using microarray systems.

Here, we present a two novel fluorescent dyes ethylenediaminechlorocholylglycinateplatinum(II), [Pt(CG)Cl(en)] complex 1 and bisursodeoxycholate(ethylenediamine)platinum(II), [Pt(UDC)(2)(en)] complex 2 based on well-known cis-platin chemistry. These platinum complexes contain cholylglycinate (CG) and ursodeoxycholate (UDC) as ligands. These compounds enable qualitative detection of double-helix DNA and quantitative detection (from pg to µg). These novel compounds have absorption and emission spectra in a difference range as the common ones (for example: cyanine dyes such as Cy3, Cy5, Cy7,…); therefore, it could allow the multi-parametric detection of DNA arrays, incrementing the capacity of experimental performance per one single array. As a consequence, it will increase the amount of data info obtained per chip. The combination of the intrinsic property of this compounds with the optical properties in different fluorescence channels, can allow introducing a new molecule with a wide range of possible applications in DNA arrays.

Procedures for controlling the size, structure and optical properties of CdS quantum dots during synthesis in aqueous solution.

We report an easy approach for the synthesis of CdS Quantum Dots (CdS QDs) with high luminescence and temporal stability through the reaction of Cd(2+) and S(2-) in the presence of mercaptoacetic acid (MAA) as a capping reagent in aqueous medium, under normal pressure and room temperature. The influence of several experimental variables, including temperature, pH, the Cd/S ratio and the Cd/MAA ratio, on the optical properties of the QDs obtained was studied systematically. The experimental results indicate that these variables play an important role in determining the size and state of the surface of the nanoparticles, and hence their luminescent properties and temporal stability. The general aspects of nanocrystal nucleation and growth in the synthesis of nanocrystals were studied. The best conditions for the synthesis of nanoparticles of high quality are also reported. The CdS nanocrystals obtained exhibited a narrow PL band, with reproducible room-temperature quantum yields.

Bisursodeoxycholate(ethylenediamine)platinum(II): a new autofluorescent compound. Cytotoxic activity and cell cycle analysis in ovarian and hematological cell lines.

The present paper describes for the first time an intrinsic fluorescent square-planar platinum(II) complex carrying two ursodeoxycholate ligands ([Pt(UDC)2(en)], where UDC(-) = ursodeoxycholate), that emits at room temperature once free in solution. Kinetic studies were carried out in aqueous solution and in the presence of different NaCl concentrations: 4 mM (similar to cytoplasmic concentration) and 150 mM (similar to plasmatic concentration). This novel compound was synthesized from a [PtCl2(en)] complex and shows increased cytotoxic activity against both resting and cycling HeLa cells, with no toxicity for cell lines derived from neoplastic haematopoietic cells.